Why PTD?

In the era of personalized medicine and personalized health there is a tremendous effort to bring NGS based technology in the clinical routine. Nevertheless, genome-wide information from research studies is in most cases useless in the clinical practice and in addition too expensive.

To bridge the gap between cancer research and clinical genomics, we propose PrecisionTrialDrawer, a suite of tools to explore the ability of cancer gene panels to be used in clinical trials.

What can you do with PTD?

Data

Design your panel and link it to specific tumor types

  • Create a Cancer Panel linking drugs to specific genes or alterations
  • Integrate genomic data like mutations, expression, copynumber and fusions
  • Use data from over 40 tumor types

Simulation

Calculate various measure of study feasibility

  • How many patients are covered by a specific mutations?
  • How many patients would be covered by a drug that acts on one or multiple targets?
  • Are the drugs covering overlapping pathways?

Power Analysis

Assure high power minimizing the number of patients to screen.

  • Innovative sample size calculation designed for genomic-driven clinical trials
  • Calculate sample size for a basket or umbrella trial with multiple drugs or tumor types
  • Given a power level to reach, analyze various simulation scenarios

Panel Design

Happy with the panel design?

  • Adjust gene size choosing what sequences to include
  • Compare covered patients VS sequencing size
  • Create a ready-to-sequence panel in bed format




Copyright © 2017 Giorgio Melloni. All rights reserved.