Sometimes I do actual science too…



2021

Cortés-Ciriano, I., Gulhan, D.C., Lee, J.JK., Melloni, G.E.M. & Park PJ Computational analysis of cancer genome sequencing data. Nat Rev Genet (2021). https://doi.org/10.1038/s41576-021-00431-y

Nicholas A. Marston, Robert P. Giugliano, MD, Giorgio E. M. Melloni, PhD et al. Association of Apolipoprotein B–Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis Distinguishing Between Particle Concentration, Type, and Content JAMA Cardiol (2021), doi:10.1001/jamacardio.2021.5083

Lumbers et al. The genomics of heart failure: design and rationale of the HERMES consortium ESC heart failure (2021), https://doi.org/10.1002/ehf2.13517

Anna Camporesi, Giorgio EM Melloni, Veronica Diotto, Patrizia Bertani, Enrico La Pergola, Gloria Pelizzo Organizational aspects of pediatric anesthesia and surgery between two waves of Covid‐19 Acta Anaesthesiologica Scandinavica 2021 65 (6), 755-760 https://doi.org/10.1111/aas.13802

GEM Melloni, JH Cook, DC Gulhan, PJ Park, KM Haigis The origins and genetic interactions of KRAS mutations are allele-and tissue-specific Nature Communications 2021 12 (1), 1-14 https://doi.org/10.5281/zenodo.4541794

Nicholas A Marston, Giorgio EM Melloni, Yared Gurmu, Marc P Bonaca, Frederick K Kamanu, Carolina Roselli, Christina Lee, Ilaria Cavallari, Robert P Giugliano, Benjamin M Scirica, Deepak L Bhatt, Philippe Gabriel Steg, Marc Cohen, Robert F Storey, Anthony C Keech, Itamar Raz, Ofri Mosenzon, Eugene Braunwald, Steven A Lubitz, Patrick T Ellinor, Marc S Sabatine, Christian T Ruff Genetic risk score to identify risk of venous thromboembolism in patients with cardiometabolic disease Circulation: Genomic and Precision Medicine 2021 14 (1), e003006 https://doi.org/10.1161/CIRCGEN.120.003006

2020

Nicholas A Marston, Yared Gurmu, Giorgio EM Melloni, Marc Bonaca, Baris Gencer, Peter S Sever, Terje R Pedersen, Anthony C Keech, Carolina Roselli, Steven A Lubitz, Patrick T Ellinor, Michelle L O’Donoghue, Robert P Giugliano, Christian T Ruff, Marc S Sabatine The effect of PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition on the risk of venous thromboembolism Circulation 141 (20), 1600-1607 (2020), https://doi.org/10.1161/CIRCULATIONAHA.120.046397

2019

Gerardo Bosco, Edoardo Ostardo, Alex Rizzato, Giacomo Garetto, Matteo Paganini, Giorgio Melloni, Giampiero Giron, Lodovico Pietrosanti, Ivo Martinelli, Enrico Camporesi Clinical and morphological effects of hyperbaric oxygen therapy in patients with interstitial cystitis associated with fibromyalgia BMC urology 19 (1), 1-7 (2019), doi:10.1186/s12894-019-0545-6

Doga C Gulhan, Jake June-Koo Lee, Giorgio EM Melloni, Isidro Cortés-Ciriano, Peter J Park Detecting the mutational signature of homologous recombination deficiency in clinical samples Nature Genetics volume 51, pages912–919 (2019), https://doi.org/10.1038/s41588-019-0390-2

Dellino GI, Palluzzi F, Piccioni R, Furia L, Melloni G, Guido D, Giacò L, Luzi L, Cittaro D, Faretta M, Crosetto N and Pelicci PG Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations Nature Genetics volume 51, pages1011–1023 (2019) https://doi.org/10.1038/s41588-019-0421-z

Santoro A, Vlachou T, Melloni G, Luzi L, Pasi C, Reavie L, Bonetti P, D’Elia E, Casoli L, Sabò A, Nicassio F, Moroni M, Dellino G, Amati, B, Pelicci PG. p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value Cell Reports, 2019, https://doi.org/10.1016/j.celrep.2018.12.071

Gilly A, Kuchenbaecker K, Southam L, Suveges D, Moore R, Melloni G, Hatzikotoulas K, Farmaki AE, Ritchie G, Schwartzentruber J, Danecek P, Kilian B, Pollard M, Ge X, Elding H, Astle W, Jiang T, Butterworth A, Soranzo N, Tsafantakis E, Karaleftheri M, Dedoussis G, Zeggini E Very low depth whole genome sequencing in complex trait association studies Bioinformatics 2019 Aug 1;35(15):2555-2561. doi: 10.1093/bioinformatics/bty1032

2018

Melloni GEM, Guida A, Curigliano G, Botteri E, Esposito A, Kamal M, Le Torneau C, Riva L, Pelicci PG and Mazzarella L. Precision Trial Drawer (PTD): a computational tool to assist planning of genomics-driven trials in oncology JCO Precision Oncology 2018:2, 1-16 doi:10.1200/PO.18.00015

GEM Melloni, G. Ukmar, L. Raddrizzani, P. Rossi, S. Di Bella, M. R. Pirchio, M. Vescovi, A. Leone, M. Callari, M. Cesarini, A. Somaschini, G. Della Vedova, MG Daidone, M. Pettenella, A. Isacchi, and R. Bosotti PATRI, a Genomics Data Integration Tool for Biomarker Discovery BioMed Research International (2018), Article ID 2012078 https://doi.org/10.1155/2018/2012078

Gilly A, Suveges D, Kuchenbaecker K, Pollard M, Southam L, Hatzikotoulas K, Farmaki AE, Bjornland T, Waples R, Appel EVR, Casalone E, Melloni G, Killian B, Rayner NW, Ntallia I, Kundu K, Walter K, Danesh J, Butterworth A, Barroso I, Tsafantakis E, Dedoussis G, Moltke I, Zeggini E Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits Nature Communications 9, Article number: 4674 (2018) https://doi.org/10.1038/s41467-018-07070-8

2017

Sanarico AG, Ronchini C, Croce A, Memmi E, Cammarata UA, De Antoni A, Larvogna S, Divona M, Giacò L, Melloni GEM, Lo Coco F, Melino G, Pelicci PG and Bernassola F The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukemia. Leukemia 32, 911–919 (2018). https://doi.org/10.1038/leu.2017.342

Richichi C, Fornasari L, Melloni GEM, Brescia P, Patanè M, Del Bene M, Mustafa DAM, Kros JM, Pollo B, Pruneri G, Sciandivasci A, Munzone E, DiMeco F, Pelicci PG, Riva L, Pelicci G. Mutations targeting the coagulation pathway are enriched in brain metastases Scientific Reports 7, Article number: 6573 (2017) doi:10.1038/s41598-017-06811-x

Melloni GEM, Mazzarella L, Russo A, Bodini M, Bernard L, Luzi L, Pelicci PG and Riva L, A knowledge based computational framework for breast cancer predisposing gene discovery using exome sequencing data Breast Cancer Research 2017 19:63 doi: 10.1186/s13058-017-0854-1

2016

Ronchini C, Brozzi A, Riva L, Luzi L, Gruszka A, Scanziani E, Melloni GE, Dharmalingam G, Mutarelli M, Belcastro V, Lavorgna S, Rossi V, Spinelli O, Biondi A, Rambaldi A, Lo-Coco F, di Bernardo D, Pelicci PG. PML-RARA—associated cooperating mutations belong to a transcriptional network that is deregulated in myeloid leukemias Leukemia. 2016 Dec 27. doi: 10.1038/leu.2016.386

Daniela Bossi, Angelo Cicalese, Gaetano I. Dellino, Lucilla Luzi, Laura Riva, Carolina D’Alesio, Giuseppe R. Diaferia, Alessandro Carugo, Elena Cavallaro, Rossana Piccioni, Massimo Barberis, Giovanni Mazzarol, Alessandro Testori, Simona Punzi, Isabella Pallavicini, Giulio Tosti, Luciano Giacó, Giorgio Melloni, Timothy P. Heffernan, Gioacchino Natoli, Giulio F. Draetta, Saverio Minucci, PierGiuseppe Pelicci and Luisa Lanfrancone In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype Cancer Discovery May 13, 2016; doi: 10.1158/2159-8290.CD-15-1200

Melloni GE, de Pretis S, Riva L, Pelizzola M, Céol A, Costanza J, Müller H, Zammataro L LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer. BMC Bioinformatics. 2016 Feb 9;17(1):80. doi: 10.1186/s12859-016-0935-7

2015

de Pretis S, Kress T, Morelli MJ, Melloni GE, Riva L, Amati B, Pelizzola M. INSPEcT: a Computational Tool to Infer mRNA Synthesis, Processing and Degradation Dynamics from RNA- and 4sU-seq Time Course Experiments , Bioinformatics (2015) doi:10.1093/bioinformatics/btv288

Bodini M, Ronchini C, Giacò L, Russo A, Melloni GEM, Luzi L, Sardella D, Volorio S, Hasan SK, Ottone T, Lavorgna S, Lo-Coco F, Candoni A, Fanin R, Toffoletti E, Iacobucci I, Martinelli G, Cignetti A, Tarella C, Bernard L, Pelicci PG, and Riva L. The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations. Blood. 2015 Jan 22;125(4):600-5. doi 10.1182/blood-2014-05-576157

2014

Melloni GEM, Ogier AGE, de Pretis S, Mazzarella L, Pelizzola M, Pelicci PG and Riva L. DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes. Genome Medicine 2014, 6:44, doi: 10.1186/gm563

2013

Riva L, Ronchini C, Bodini M, Lo-Coco F, Lavorgna S, Ottone T, Martinelli G, Iacobucci I, Tarella C, Cignetti A, Volorio S, Bernard L, Russo A, Melloni GEM, Luzi L, Alcalay M, Dellino GI, Pelicci PG. Acute promyelocytic leukemias share cooperative mutations with other myeloid-leukemia subgroups. Blood Cancer Journal 2013 Sep 13;3:e147. doi: 10.1038/bcj.2013.46.